Uninstall Pl-2303 on Mac OSX
If you have a Mac and want to uninstall the PL-2303 USB to Serial driver then you’ll need some luck and some terminal skills. We do not support removal of prolific drivers, but these steps should do the trick.
Follow these steps:
1. Open “Applications-> Utilities-> Terminal”. You need to create ID & password first on NetInfo Manager.
2. Login to root user and type “su” and enter password.
3. Type “cd /System/Library/Extensions” to go to the “Extensions” folder.
4. Unload the driver (if it had been loaded) by typing “kextunload PL2303.kext” or “kextunload ProlificUsbSerial.kext”
5. Remove the driver by typing “rm -r PL2303.kext” or “rm -r ProlificUsbSerial.kext”.